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Structural basis of IFNα receptor recognition by TYK2
Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family of non-receptor tyrosine kinases, which are essential for proper signaling in immune responses and development. Here we present a 2.0 angstrom resolution crystal structure of a receptor-binding fragment of human TYK2 encompassing...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4161281/ https://ncbi.nlm.nih.gov/pubmed/24704786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2807 |
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