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Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation
Cytokines and interferons initiate intracellular signaling via receptor dimerization and activation of Janus kinases (JAKs). How JAKs structurally respond to changes in receptor conformation induced by ligand binding is not known. Here, we present two crystal structures of the human JAK2 FERM and SH...
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| Published in: | eLife |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
eLife Sciences Publications, Ltd
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6078494/ https://ncbi.nlm.nih.gov/pubmed/30044226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38089 |
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