The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK–Receptor Interactions

Por Ferrao, Ryan, Lupardus, Patrick J.
Publicado no Front Endocrinol (Lausanne) (2017)

Phosphorylation of Xenopus Rad1 and Hus1 Defines a Readout for ATR Activation That Is Independent of Claspin and the Rad9 Carboxy Terminus

Por Lupardus, Patrick J., Cimprich, Karlene A.
Publicado em 2006

The structure of Interleukin-23 reveals the molecular basis of p40 subunit sharing with IL-12

Por Lupardus, Patrick J., Garcia, K. Christopher
Publicado em 2008

Analyzing the ATR-mediated checkpoint using Xenopus egg extracts

Por Lupardus, Patrick J., Van, Christopher, Cimprich, Karlene A.
Publicado em 2007

Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Rα2

Por Lupardus, Patrick J., Birnbaum, Michael E., Garcia, K. Christopher
Publicado em 2010

Small molecule-induced allosteric activation of the V. cholerae RTX cysteine protease domain

Por Lupardus, Patrick J., Shen, Aimee, Bogyo, Matthew, Garcia, K. Christopher
Publicado em 2008

CPDadh: A new peptidase family homologous to the cysteine protease domain in bacterial MARTX toxins

Por Pei, Jimin, Lupardus, Patrick J, Garcia, K Christopher, Grishin, Nick V
Publicado em 2009

A requirement for replication in activation of the ATR-dependent DNA damage checkpoint

Por Lupardus, Patrick J., Byun, Tony, Yee, Muh-ching, Hekmat-Nejad, Mohammad, Cimprich, Karlene A.
Publicado em 2002

Structural basis of IFNα receptor recognition by TYK2

Por Wallweber, Heidi J.A., Tam, Christine, Franke, Yvonne, Starovasnik, Melissa A., Lupardus, Patrick J.
Publicado em 2014

Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

Por Lupardus, Patrick J., Ultsch, Mark, Wallweber, Heidi, Bir Kohli, Pawan, Johnson, Adam R., Eigenbrot, Charles
Publicado em 2014

K(+) channel modulation in rodent neurohypophysial nerve terminals by sigma receptors and not by dopamine receptors

Por Wilke, Russell A, Lupardus, Patrick J, Grandy, David K, Rubinstein, Marcelo, Low, Malcolm J, Jackson, Meyer B
Publicado em 1999

Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex

Por Lupardus, Patrick J., Skiniotis, Georgios, Rice, Amanda J., Thomas, Christoph, Fischer, Suzanne, Walz, Thomas, Garcia, K. Christopher
Publicado em 2011

The Structural Basis for Class II Cytokine Receptor Recognition by JAK1

Por Ferrao, Ryan, Wallweber, Heidi J.A., Ho, Hoangdung, Tam, Christine, Franke, Yvonne, Quinn, John, Lupardus, Patrick J.
Publicado no Structure (2016)

Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase η on ATR checkpoint signaling

Por Bomgarden, Ryan D, Lupardus, Patrick J, Soni, Deena V, Yee, Muh-Ching, Ford, James M, Cimprich, Karlene A
Publicado em 2006

Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase η on ATR checkpoint signaling

Por Bomgarden, Ryan D, Lupardus, Patrick J, Soni, Deena V, Yee, Muh-Ching, Ford, James M, Cimprich, Karlene A
Publicado em 2006

Simplified, Enhanced Protein Purification Using an Inducible, Autoprocessing Enzyme Tag

Por Shen, Aimee, Lupardus, Patrick J., Morell, Montse, Ponder, Elizabeth L., Sadaghiani, A. Masoud, Garcia, K. Christopher, Bogyo, Matthew
Publicado em 2009

Mechanistic and structural insights into the proteolytic activation of Vibrio cholera MARTX toxin

Por Shen, Aimee, Lupardus, Patrick J., Albrow, Victoria E., Guzzetta, Andrew, Powers, James C., Garcia, K. Christopher, Bogyo, Matthew
Publicado em 2009

Rational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdB

Por Puri, Aaron W., Lupardus, Patrick J., Deu, Edgar, Albrow, Victoria E., Garcia, K. Christopher, Bogyo, Matthew, Shen, Aimee
Publicado em 2010

Membrane-delimited coupling between sigma receptors and K(+) channels in rat neurohypophysial terminals requires neither G-protein nor ATP

Por Lupardus, Patrick J, Wilke, Russell A, Aydar, Ebru, Palmer, Chris P, Chen, Yuenmu, Ruoho, Arnold E, Jackson, Meyer B
Publicado em 2000

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins

Por Shen, Aimee, Lupardus, Patrick J., Puri, Aaron W., Albrow, Victoria E., Gersch, Malte M., Garcia, K. Christopher, Bogyo, Matthew
Publicado em 2011