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Small molecule-induced allosteric activation of the V. cholerae RTX cysteine protease domain
A eukaryotic-specific small molecule activates the protease domain of a Vibrio cholerae toxin, resulting in toxin autoprocessing and activation. Vibrio cholerae RTX (Repeats-in-Toxin) is an actin-disrupting toxin that is autoprocessed by an internal cysteine protease domain (CPD). The RTX CPD is eff...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272704/ https://ncbi.nlm.nih.gov/pubmed/18845756 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1162403 |
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