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Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins
An internal cysteine protease domain (CPD) autoproteolytically regulates Clostridium difficile glucosylating toxins by releasing a cytotoxic effector domain into target cells. CPD activity is itself allosterically regulated by the eukaryotic-specific molecule inositol hexakisphosphate (InsP(6)). Alt...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076311/ https://ncbi.nlm.nih.gov/pubmed/21317893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1990 |
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