Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins

An internal cysteine protease domain (CPD) autoproteolytically regulates Clostridium difficile glucosylating toxins by releasing a cytotoxic effector domain into target cells. CPD activity is itself allosterically regulated by the eukaryotic-specific molecule inositol hexakisphosphate (InsP(6)). Alt...

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Bibliografiske detaljer
Main Authors: Shen, Aimee, Lupardus, Patrick J., Puri, Aaron W., Albrow, Victoria E., Gersch, Malte M., Garcia, K. Christopher, Bogyo, Matthew
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076311/
https://ncbi.nlm.nih.gov/pubmed/21317893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1990
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