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Rational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdB
Clostridium difficile is a leading cause of nosocomial infections. The major virulence factors of this pathogen are the multidomain toxins TcdA and TcdB. These toxins contain a cysteine protease domain (CPD) that autoproteolytically releases a cytotoxic effector domain upon binding intracellular ino...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005307/ https://ncbi.nlm.nih.gov/pubmed/21095570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.09.011 |
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