Rational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdB

Clostridium difficile is a leading cause of nosocomial infections. The major virulence factors of this pathogen are the multidomain toxins TcdA and TcdB. These toxins contain a cysteine protease domain (CPD) that autoproteolytically releases a cytotoxic effector domain upon binding intracellular ino...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Puri, Aaron W., Lupardus, Patrick J., Deu, Edgar, Albrow, Victoria E., Garcia, K. Christopher, Bogyo, Matthew, Shen, Aimee
Formato: Artigo
Idioma:Inglês
Publicado: 2010
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005307/
https://ncbi.nlm.nih.gov/pubmed/21095570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.09.011
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares