Lectin Activity of the TcdA and TcdB Toxins of Clostridium difficile

Clostridium difficile is a major cause of hospital-acquired antibiotic-associated diarrhea. C. difficile produces two cytotoxins, TcdA and TcdB; both toxins are multidomain proteins that lead to cytotoxicity through the modification and inactivation of small GTPases of the Rho/Rac family. Previous s...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Hartley-Tassell, Lauren E., Awad, Milena M., Seib, Kate L., Scarselli, Maria, Savino, Silvana, Tiralongo, Joe, Lyras, Dena, Day, Christopher J., Jennings, Michael P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386544/
https://ncbi.nlm.nih.gov/pubmed/30530621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00676-18
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