Clostridium difficile Toxins TcdA and TcdB Cause Colonic Tissue Damage by Distinct Mechanisms

As the major cause of antibiotic-associated diarrhea, Clostridium difficile is a serious problem in health care facilities worldwide. C. difficile produces two large toxins, TcdA and TcdB, which are the primary virulence factors in disease. The respective functions of these toxins have been difficul...

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Bibliographic Details
Published in:Infect Immun
Main Authors: Chumbler, Nicole M., Farrow, Melissa A., Lapierre, Lynne A., Franklin, Jeffrey L., Lacy, D. Borden
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038081/
https://ncbi.nlm.nih.gov/pubmed/27456833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00583-16
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