Clostridium difficile Toxins TcdA and TcdB Cause Colonic Tissue Damage by Distinct Mechanisms

As the major cause of antibiotic-associated diarrhea, Clostridium difficile is a serious problem in health care facilities worldwide. C. difficile produces two large toxins, TcdA and TcdB, which are the primary virulence factors in disease. The respective functions of these toxins have been difficul...

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Veröffentlicht in:Infect Immun
Hauptverfasser: Chumbler, Nicole M., Farrow, Melissa A., Lapierre, Lynne A., Franklin, Jeffrey L., Lacy, D. Borden
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038081/
https://ncbi.nlm.nih.gov/pubmed/27456833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00583-16
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