The Structural Basis for Class II Cytokine Receptor Recognition by JAK1

JAK1 is a member of the Janus kinase (JAK) family of non-receptor tyrosine kinases that are activated in response to cytokines and interferons. Here we present two crystal structures of the human JAK1 FERM and SH2 domains bound to peptides derived from the class II cytokine receptors IFN-λ receptor...

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Bibliographic Details
Published in:Structure
Main Authors: Ferrao, Ryan, Wallweber, Heidi J.A., Ho, Hoangdung, Tam, Christine, Franke, Yvonne, Quinn, John, Lupardus, Patrick J.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899269/
https://ncbi.nlm.nih.gov/pubmed/27133025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.03.023
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