A requirement for replication in activation of the ATR-dependent DNA damage checkpoint

Using the Xenopus egg extract system, we investigated the involvement of DNA replication in activation of the DNA damage checkpoint. We show here that DNA damage slows replication in a checkpoint-independent manner and is accompanied by replication-dependent recruitment of ATR and Rad1 to chromatin....

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Detalhes bibliográficos
Main Authors: Lupardus, Patrick J., Byun, Tony, Yee, Muh-ching, Hekmat-Nejad, Mohammad, Cimprich, Karlene A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2002
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC187437/
https://ncbi.nlm.nih.gov/pubmed/12231621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1013502
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