A requirement for replication in activation of the ATR-dependent DNA damage checkpoint

Using the Xenopus egg extract system, we investigated the involvement of DNA replication in activation of the DNA damage checkpoint. We show here that DNA damage slows replication in a checkpoint-independent manner and is accompanied by replication-dependent recruitment of ATR and Rad1 to chromatin....

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Détails bibliographiques
Auteurs principaux: Lupardus, Patrick J., Byun, Tony, Yee, Muh-ching, Hekmat-Nejad, Mohammad, Cimprich, Karlene A.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2002
Sujets:
Research Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC187437/
https://ncbi.nlm.nih.gov/pubmed/12231621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1013502
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