Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint

The ATR-dependent DNA damage response pathway can respond to a diverse group of lesions as well as inhibitors of DNA replication. Using the Xenopus egg extract system, we show that lesions induced by UV irradiation and cis-platinum cause the functional uncoupling of MCM helicase and DNA polymerase a...

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Detalhes bibliográficos
Main Authors: Byun, Tony S., Pacek, Marcin, Yee, Muh-ching, Walter, Johannes C., Cimprich, Karlene A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1091739/
https://ncbi.nlm.nih.gov/pubmed/15833913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1301205
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