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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
The ATR-dependent DNA damage response pathway can respond to a diverse group of lesions as well as inhibitors of DNA replication. Using the Xenopus egg extract system, we show that lesions induced by UV irradiation and cis-platinum cause the functional uncoupling of MCM helicase and DNA polymerase a...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2005
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1091739/ https://ncbi.nlm.nih.gov/pubmed/15833913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1301205 |
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