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The structure of Interleukin-23 reveals the molecular basis of p40 subunit sharing with IL-12

Interleukin-23 is a recently identified member of the IL-12 family of heterodimeric cytokines that modulate subpopulations of T helper cells, and both IL-12 and IL-23 are attractive targets for therapy of autoimmune diseases. IL-23 is a binary complex of a four-helix bundle cytokine (p19) and a solu...

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Autors principals: Lupardus, Patrick J., Garcia, K. Christopher
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666310/
https://ncbi.nlm.nih.gov/pubmed/18680750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.07.051
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