The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects

Interleukin (IL)-23 is a heterodimeric cytokine consisting of a novel p19 molecule and the p40 subunit of IL-12. Since secreted p40 can act as an antagonist for IL-12, we investigated whether p40 also inhibited IL-23-mediated immunological functions. p40 did not induce interferon (IFN)-γ or IL-17 pr...

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Detalhes bibliográficos
Main Authors: Shimozato, Osamu, Ugai, Shin-ichi, Chiyo, Masako, Takenobu, Hisanori, Nagakawa, Hiroyasu, Wada, Akihiko, Kawamura, Kiyoko, Yamamoto, Hiroshi, Tagawa, Masatoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782201/
https://ncbi.nlm.nih.gov/pubmed/16423037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2005.02257.x
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