Structural basis for IL-12 and IL-23 shared receptor usage reveals a gateway for shaping actions on T versus NK cells

Interleukin-12 (IL-12) and IL-23 are heterodimeric cytokines produced by antigen presenting cells to regulate the activation and differentiation of lymphocytes and which share IL-12Rβ1 as a receptor signaling subunit. We present a crystal structure of the quaternary IL-23(IL-23p19/p40)/IL-23R/IL-12R...

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Publicado no:Cell
Main Authors: Glassman, Caleb R., Mathiharan, Yamuna Kalyani, Jude, Kevin M., Su, Leon, Panova, Ouliana, Lupardus, Patrick J., Spangler, Jamie B., Ely, Lauren K., Thomas, Christoph, Skiniotis, Georgios, Garcia, K. Christopher
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899134/
https://ncbi.nlm.nih.gov/pubmed/33606986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.01.018
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