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Structural basis for IL-12 and IL-23 shared receptor usage reveals a gateway for shaping actions on T versus NK cells
Interleukin-12 (IL-12) and IL-23 are heterodimeric cytokines produced by antigen presenting cells to regulate the activation and differentiation of lymphocytes and which share IL-12Rβ1 as a receptor signaling subunit. We present a crystal structure of the quaternary IL-23(IL-23p19/p40)/IL-23R/IL-12R...
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| 出版年: | Cell |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2021
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7899134/ https://ncbi.nlm.nih.gov/pubmed/33606986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.01.018 |
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