Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP

ML-IAP (melanoma inhibitor of apoptosis) is a potent anti-apoptotic protein that is strongly up-regulated in melanoma and confers protection against a variety of pro-apoptotic stimuli. The mechanism by which ML-IAP regulates apoptosis is unclear, although weak inhibition of caspases 3 and 9 has been...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Vucic, Domagoj, Franklin, Matthew C., Wallweber, Heidi J. A., Das, Kanad, Eckelman, Brendan P., Shin, Hwain, Elliott, Linda O., Kadkhodayan, Saloumeh, Deshayes, Kurt, Salvesen, Guy S., Fairbrother, Wayne J.
Format: Artigo
Langue:Inglês
Publié: Portland Press Ltd. 2004
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134668/
https://ncbi.nlm.nih.gov/pubmed/15485396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041108
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires