Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP

ML-IAP (melanoma inhibitor of apoptosis) is a potent anti-apoptotic protein that is strongly up-regulated in melanoma and confers protection against a variety of pro-apoptotic stimuli. The mechanism by which ML-IAP regulates apoptosis is unclear, although weak inhibition of caspases 3 and 9 has been...

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Autori principali: Vucic, Domagoj, Franklin, Matthew C., Wallweber, Heidi J. A., Das, Kanad, Eckelman, Brendan P., Shin, Hwain, Elliott, Linda O., Kadkhodayan, Saloumeh, Deshayes, Kurt, Salvesen, Guy S., Fairbrother, Wayne J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2004
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134668/
https://ncbi.nlm.nih.gov/pubmed/15485396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041108
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