Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase

Eitemau Tebyg

• Immunity to the melanoma inhibitor of apoptosis protein (ML-IAP; livin) in patients with malignant melanoma
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• Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP
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• Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells
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  Cyhoeddwyd: (2004)
• Activation of Dual Apoptotic Pathways in Human Melanocytes and Protection by Survivin
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• IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.
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