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Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge
Human β-tryptase, a tetrameric trypsin-like serine protease, is an important mediator of allergic inflammatory responses in asthma. Antibodies generally inhibit proteases by blocking substrate access by binding to active sites or exosites or by allosteric modulation. The bivalency of IgG antibodies...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7755903/ https://ncbi.nlm.nih.gov/pubmed/33353951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20143-x |
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