Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge

Human β-tryptase, a tetrameric trypsin-like serine protease, is an important mediator of allergic inflammatory responses in asthma. Antibodies generally inhibit proteases by blocking substrate access by binding to active sites or exosites or by allosteric modulation. The bivalency of IgG antibodies...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Maun, Henry R., Vij, Rajesh, Walters, Benjamin T., Morando, Ashley, Jackman, Janet K., Wu, Ping, Estevez, Alberto, Chen, Xiaocheng, Franke, Yvonne, Lipari, Michael T., Dennis, Mark S., Kirchhofer, Daniel, Ciferri, Claudio, Loyet, Kelly M., Yi, Tangsheng, Eigenbrot, Charles, Lazarus, Robert A., Koerber, James T.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755903/
https://ncbi.nlm.nih.gov/pubmed/33353951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20143-x
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