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A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human β-Tryptase
β-Tryptase is released from mast cells upon degranulation in response to allergic and inflammatory stimuli. Human tryptase is a homotetrameric serine protease with four identical active sites directed towards a central pore. These active sites present an optimized scenario for the rational design of...
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| Publicado no: | Pharmacology |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6242772/ https://ncbi.nlm.nih.gov/pubmed/30134249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000492078 |
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