Potent selective nonpeptidic inhibitors of human lung tryptase

Human lung tryptase, a homotetrameric serine protease unique to mast cell secretory granules, has been implicated in the pathogenesis of asthma. A hypothesis that tethered symmetrical inhibitors might bridge two adjacent active sites was explored via a rationally designed series of bisbenzamidines....

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Detalhes bibliográficos
Main Authors: Burgess, Laurence E., Newhouse, Bradley J., Ibrahim, Prabha, Rizzi, James, Kashem, Mohammed A., Hartman, Ann, Brandhuber, Barbara J., Wright, Clifford D., Thomson, David S., Vigers, Guy P. A., Koch, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC17520/
https://ncbi.nlm.nih.gov/pubmed/10411878
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