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Biochemical and pharmacological profile of a potent and selective nonpeptide antagonist of the neurotensin receptor.

We describe the characteristics of SR 48692, a selective, nonpeptide antagonist of the neurotensin receptor. In vitro, this compound competitively inhibits 125I-labeled neurotensin binding to the high-affinity binding site present in brain tissue from various species with IC50 values of 0.99 +/- 0.1...

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Hlavní autoři: Gully, D, Canton, M, Boigegrain, R, Jeanjean, F, Molimard, J C, Poncelet, M, Gueudet, C, Heaulme, M, Leyris, R, Brouard, A
Médium: Artigo
Jazyk:Inglês
Vydáno: 1993
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC45600/
https://ncbi.nlm.nih.gov/pubmed/8380498
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