SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist.

An extremely potent and highly specific non-peptide, subnanomolar endothelin (ET) receptor antagonist, SB 209670, has been synthesized and characterized. SB 209670, which was rationally designed using conformational models of ET-1, selectively inhibits binding of 125I-labeled ET-1 to cloned human ET...

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Autors principals: Ohlstein, E H, Nambi, P, Douglas, S A, Edwards, R M, Gellai, M, Lago, A, Leber, J D, Cousins, R D, Gao, A, Frazee, J S
Format: Artigo
Idioma:Inglês
Publicat: 1994
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC44543/
https://ncbi.nlm.nih.gov/pubmed/8058755
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