SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist.

An extremely potent and highly specific non-peptide, subnanomolar endothelin (ET) receptor antagonist, SB 209670, has been synthesized and characterized. SB 209670, which was rationally designed using conformational models of ET-1, selectively inhibits binding of 125I-labeled ET-1 to cloned human ET...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ohlstein, E H, Nambi, P, Douglas, S A, Edwards, R M, Gellai, M, Lago, A, Leber, J D, Cousins, R D, Gao, A, Frazee, J S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44543/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8058755/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.17.8052
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