Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase

[Image: see text] Tryptase, a serine protease released from mast cells, is implicated in many allergic and inflammatory disorders. Human tryptase is a donut-shaped tetramer with the active sites facing inward forming a central pore. Bivalent ligands spanning two active sites potently inhibit this co...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:ACS Med Chem Lett
Hlavní autoři: Giardina, Sarah F., Werner, Douglas S., Pingle, Maneesh, Foreman, Kenneth W., Bergstrom, Donald E., Arnold, Lee D., Barany, Francis
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2018
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6088348/
https://ncbi.nlm.nih.gov/pubmed/30128075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00204
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky