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Novel bivalent securinine mimetics as topoisomerase I inhibitors
A series of novel bivalent securinine mimetics incorporating different linkers between C-15 and C-15′ were synthesized and their topoisomerase I (Topo I) inhibitory activities evaluated. It was thus revealed that mimetic R2 incorporating a rigid m-substituted benzene linker exhibits Topo I inhibitor...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Medchemcomm |
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| Κύριοι συγγραφείς: | , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Royal Society of Chemistry
2017
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6072210/ https://ncbi.nlm.nih.gov/pubmed/30108747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6md00563b |
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