Interaction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein,

We have designed and synthesized a cyclic, bivalent Smac mimetic (compound 3) and characterized its interaction with the X-linked inhibitor of apoptosis protein (XIAP). Compound 3 binds to XIAP containing both BIR2 and BIR3 domains with a biphasic dose–response curve representing two binding sites w...

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Detalhes bibliográficos
Main Authors: Nikolovska-Coleska, Zaneta, Meagher, Jennifer L., Jiang, Sheng, Yang, Chao-Yie, Qiu, Su, Roller, Peter P., Stuckey, Jeanne A., Wang, Shaomeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784912/
https://ncbi.nlm.nih.gov/pubmed/18717598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800785y
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