Structure-Based Design, Synthesis, Evaluation and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP)

Small molecules designed to mimic the binding of Smac protein to X-linked inhibitor of apoptosis protein (XIAP) are being pursued as a promising new class of anticancer drugs. Herein, we report the design, synthesis, and comprehensive structure-activity relationship studies of a series of conformati...

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Detalhes bibliográficos
Main Authors: Sun, Haiying, Stuckey, Jeanne A., Zaneta, Nikolovska-Coleska, Qin, Dongguang, Meagher, Jennifer L., Qiu, Su, Lu, Jianfeng, Yang, Chao-Yie, Saito, Naoyuki G., Wang, Shaomeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688463/
https://ncbi.nlm.nih.gov/pubmed/18954041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8006849
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