SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP

Small-molecule Smac mimetics are being developed as a novel class of anticancer drugs. Recent studies have shown that Smac mimetics target cellular inhibitor of apoptosis protein (cIAP)-1/2for degradation and induce tumor necrosis factor-α (TNFα)–dependent apoptosis in tumor cells. In this study, we...

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Detalhes bibliográficos
Main Authors: Lu, Jianfeng, Bai, Longchuan, Sun, Haiying, Nikolovska-Coleska, Zaneta, McEachern, Donna, Qiu, Su, Miller, Rebecca S., Yi, Han, Shangary, Sanjeev, Sun, Yi, Meagher, Jennifer L., Stuckey, Jeanne A., Wang, Shaomeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784911/
https://ncbi.nlm.nih.gov/pubmed/19010913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-2655
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