載入...

Design, Synthesis and Characterization of A Potent, Non-Peptide, Cell-Permeable, Bivalent Smac Mimetic that Concurrently Targets both the BIR2 and BIR3 Domains in XIAP

XIAP is a central apoptosis regulator that inhibits apoptosis by binding to and inhibiting the effectors caspase-3/-7 and an initiator caspase-9 through its BIR2 and BIR3 domains, respectively. Smac protein in its dimeric form effectively antagonizes XIAP by concurrently targeting both its BIR2 and...

全面介紹

Na minha lista:
書目詳細資料
Main Authors: Sun, Haiying, Nikolovska-Coleska, Zaneta, Lu, Jianfeng, Meagher, Jennifer L., Yang, Chao-Yie, Qiu, Su, Tomita, York, Ueda, Yumi, Jiang, Sheng, Krajewski, Krzysztof, Roller, Peter P., Stuckey, Jeanne A., Wang, Shaomeng
格式: Artigo
語言:Inglês
出版: 2007
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553712/
https://ncbi.nlm.nih.gov/pubmed/17999504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja074725f
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!