Potent Bivalent Smac Mimetics: Effect of the Linker on Binding to Inhibitor of Apoptosis Proteins (IAPs) and Anticancer Activity

We have synthesized and evaluated a series of non-peptidic, bivalent Smac mimetics as antagonists of the inhibitor of apoptosis proteins and new anticancer agents. All these bivalent Smac mimetics bind to full-length XIAP with low nanomolar affinities and function as ultra-potent antagonists of XIAP...

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Detalhes bibliográficos
Main Authors: Sun, Haiying, Liu, Liu, Lu, Jianfeng, Bai, Longchuan, Li, Xiaoqin, Nikolovska-Coleska, Zaneta, McEachern, Donna, Yang, Chao-Yie, Qiu, Su, Yi, Han, Sun, Duxin, Wang, Shaomeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108148/
https://ncbi.nlm.nih.gov/pubmed/21462933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101651b
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