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LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling

Smac mimetics block inhibitor of apoptosis (IAP) proteins to trigger TNFα-dependent apoptosis in cancer cells. However, only a small subset of cancer cells appear to be sensitive to Smac mimetics and even sensitive cells can develop resistance. Herein, we elucidated mechanisms underlying the intrins...

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Bibliografske podrobnosti
Main Authors: Bai, Longchuan, McEachern, Donna, Yang, Chao-Yie, Lu, Jianfeng, Sun, Haiying, Wang, Shaomeng
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294058/
https://ncbi.nlm.nih.gov/pubmed/22241084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-2428
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