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Design, Synthesis and Characterization of A Potent, Non-Peptide, Cell-Permeable, Bivalent Smac Mimetic that Concurrently Targets both the BIR2 and BIR3 Domains in XIAP

XIAP is a central apoptosis regulator that inhibits apoptosis by binding to and inhibiting the effectors caspase-3/-7 and an initiator caspase-9 through its BIR2 and BIR3 domains, respectively. Smac protein in its dimeric form effectively antagonizes XIAP by concurrently targeting both its BIR2 and...

詳細記述

保存先:
書誌詳細
主要な著者: Sun, Haiying, Nikolovska-Coleska, Zaneta, Lu, Jianfeng, Meagher, Jennifer L., Yang, Chao-Yie, Qiu, Su, Tomita, York, Ueda, Yumi, Jiang, Sheng, Krajewski, Krzysztof, Roller, Peter P., Stuckey, Jeanne A., Wang, Shaomeng
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553712/
https://ncbi.nlm.nih.gov/pubmed/17999504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja074725f
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