Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist

Hepatocyte growth factor (HGF), the ligand for the receptor tyrosine kinase Met, is secreted as single chain pro-HGF that lacks signaling activity. Pro-HGF acquires functional competence upon cleavage between R494 and V495, generating a disulfide-linked α/β-heterodimer, where the β-chain of HGF (HGF...

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Detalhes bibliográficos
Main Authors: Kirchhofer, Daniel, Lipari, Michael T., Santell, Lydia, Billeci, Karen L., Maun, Henry R., Sandoval, Wendy N., Moran, Paul, Ridgway, John, Eigenbrot, Charles, Lazarus, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828710/
https://ncbi.nlm.nih.gov/pubmed/17372204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700184104
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