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Structural insight into distinct mechanisms of protease inhibition by antibodies
To better understand how the relatively flat antigen-combining sites of antibodies interact with the concave shaped substrate-binding clefts of proteases, we determined the structures of two antibodies in complex with the trypsin-like hepatocyte growth-factor activator (HGFA). The two inhibitory ant...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2148376/ https://ncbi.nlm.nih.gov/pubmed/18077410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708251104 |
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