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Structural basis of the broadly neutralizing anti-interferon-α antibody rontalizumab

Interferons-alpha (IFN-α) are the expressed gene products comprising thirteen type I interferons with protein pairwise sequence similarities in the 77–96% range. Three other widely expressed human type I interferons, IFN-β, IFN-κ and IFN-ω have sequences 29–33%, 29–32% and 56–60% similar to the IFN-...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Maurer, Brigitte, Bosanac, Ivan, Shia, Steven, Kwong, Mandy, Corpuz, Racquel, Vandlen, Richard, Schmidt, Kerstin, Eigenbrot, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570538/
https://ncbi.nlm.nih.gov/pubmed/26099203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2729
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