Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01

Potent and broadly neutralizing antibodies (bnAbs) are the hallmark of HIV-1 protection by vaccination. The membrane-proximal external region (MPER) of the HIV-1 gp41 fusion protein is targeted by the most broadly reactive HIV-1 neutralizing antibodies. Here, we examine the structural and molecular...

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Vydáno v:Cell Host Microbe
Hlavní autoři: Pinto, Dora, Fenwick, Craig, Caillat, Christophe, Silacci, Chiara, Guseva, Serafima, Dehez, François, Chipot, Christophe, Barbieri, Sonia, Minola, Andrea, Jarrossay, David, Tomaras, Georgia D., Shen, Xiaoying, Riva, Agostino, Tarkowski, Maciej, Schwartz, Olivier, Bruel, Timothée, Dufloo, Jérémy, Seaman, Michael S., Montefiori, David C., Lanzavecchia, Antonio, Corti, Davide, Pantaleo, Giuseppe, Weissenhorn, Winfried
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6854463/
https://ncbi.nlm.nih.gov/pubmed/31653484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2019.09.016
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