Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity

Human high-affinity antibodies to pathogens often recognize unrelated ligands. The molecular origin and the role of this polyreactivity are largely unknown. Here, we report that HIV-1 broadly neutralizing antibodies (bNAbs) are frequently polyreactive, cross-reacting with non-HIV-1 molecules, includ...

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Publicat a:Cell Rep
Autors principals: Prigent, Julie, Jarossay, Annaëlle, Planchais, Cyril, Eden, Caroline, Dufloo, Jérémy, Kök, Ayrin, Lorin, Valérie, Vratskikh, Oxana, Couderc, Thérèse, Bruel, Timothée, Schwartz, Olivier, Seaman, Michael S., Ohlenschläger, Oliver, Dimitrov, Jordan D., Mouquet, Hugo
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5990490/
https://ncbi.nlm.nih.gov/pubmed/29847789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.101
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