Pharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates

Por Dostalek, Miroslav, Prueksaritanont, Thomayant, Kelley, Robert F.
Publicado no MAbs (2017)

High Affinity Antigen Recognition of the Dual Specific Variants of Herceptin Is Entropy-Driven in Spite of Structural Plasticity

Por Bostrom, Jenny, Haber, Lauric, Koenig, Patrick, Kelley, Robert F., Fuh, Germaine
Publicado em 2011

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys

Por Leabman, Maya K, Meng, Y Gloria, Kelley, Robert F, DeForge, Laura E, Cowan, Kyra J, Iyer, Suhasini
Publicado em 2013

Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity

Por Shatz, Whitney, Chung, Shan, Li, Bing, Marshall, Brett, Tejada, Max, Phung, Wilson, Sandoval, Wendy, Kelley, Robert F, Scheer, Justin M
Publicado em 2013

In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation

Por Li, Bing, Fouts, Ashley E, Stengel, Katharina, Luan, Peng, Dillon, Michael, Liang, Wei-Ching, Feierbach, Becket, Kelley, Robert F, Hötzel, Isidro
Publicado em 2014

Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite

Por Katschke, Kenneth J., Wu, Ping, Ganesan, Rajkumar, Kelley, Robert F., Mathieu, Mary A., Hass, Philip E., Murray, Jeremy, Kirchhofer, Daniel, Wiesmann, Christian, van Lookeren Campagne, Menno
Publicado em 2012

Improving Therapeutic Efficacy of a Complement Receptor by Structure-based Affinity Maturation

Por Li, Bing, Xi, Hongkang, Diehl, Lauri, Lee, Wyne P., Sturgeon, Lizette, Chinn, Jason, DeForge, Laura, Kelley, Robert F., Wiesmann, Christian, van Lookeren Campagne, Menno, Sidhu, Sachdev S.
Publicado em 2009

Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display

Por Nair, Pradeep M., Flores, Heather, Gogineni, Alvin, Marsters, Scot, Lawrence, David A., Kelley, Robert F., Ngu, Hai, Sagolla, Meredith, Komuves, Laszlo, Bourgon, Richard, Settleman, Jeffrey, Ashkenazi, Avi
Publicado no Proc Natl Acad Sci U S A (2015)

Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation

Por Gong, Qian, Hazen, Meredith, Marshall, Brett, Crowell, Susan R., Ou, Qinglin, Wong, Athena W., Phung, Wilson, Vernes, Jean-Michel, Meng, Y. Gloria, Tejada, Max, Andersen, Dana, Kelley, Robert F.
Publicado no MAbs (2016)

A strategy for risk mitigation of antibodies with fast clearance

Por Hötzel, Isidro, Theil, Frank-Peter, Bernstein, Lisa J., Prabhu, Saileta, Deng, Rong, Quintana, Leah, Lutman, Jeff, Sibia, Renuka, Chan, Pamela, Bumbaca, Daniela, Fielder, Paul, Carter, Paul J., Kelley, Robert F.
Publicado em 2012

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge

Por Li, Bing, Tesar, Devin, Boswell, C Andrew, Cahaya, Hendry S, Wong, Anne, Zhang, Jianhuan, Meng, Y Gloria, Eigenbrot, Charles, Pantua, Homer, Diao, Jinyu, Kapadia, Sharookh B, Deng, Rong, Kelley, Robert F
Publicado no MAbs (2014)

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

Por Sharma, Vikas K., Patapoff, Thomas W., Kabakoff, Bruce, Pai, Satyan, Hilario, Eric, Zhang, Boyan, Li, Charlene, Borisov, Oleg, Kelley, Robert F., Chorny, Ilya, Zhou, Joe Z., Dill, Ken A., Swartz, Trevor E.
Publicado no Proc Natl Acad Sci U S A (2014)

Improved Quantitative Mass Spectrometry Methods for Characterizing Complex Ubiquitin Signals

Por Phu, Lilian, Izrael-Tomasevic, Anita, Matsumoto, Marissa L., Bustos, Daisy, Dynek, Jasmin N., Fedorova, Anna V., Bakalarski, Corey E., Arnott, David, Deshayes, Kurt, Dixit, Vishva M., Kelley, Robert F., Vucic, Domagoj, Kirkpatrick, Donald S.
Publicado em 2011

IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding

Por Hymowitz, Sarah G., Filvaroff, Ellen H., Yin, JianPing, Lee, James, Cai, Liping, Risser, Philip, Maruoka, Miko, Mao, Weiguang, Foster, Jessica, Kelley, Robert F., Pan, Guohua, Gurney, Austin L., de Vos, Abraham M., Starovasnik, Melissa A.
Publicado em 2001

Generation and characterization of a unique reagent that recognizes a panel of recombinant human monoclonal antibody therapeutics in the presence of endogenous human IgG

Por Wang, Xiangdan, Quarmby, Valerie, Ng, Carl, Chuntharapai, Anan, Shek, Theresa, Eigenbrot, Charles, Kelley, Robert F., Shia, Steven, McCutcheon, Krista M, Lowe, John, Leddy, Cecilia, Coachman, Kyle, Cain, Gary, Chu, Felix, Hotzel, Isidro, Maia, Mauricio, Wakshull, Eric, Yang, Jihong
Publicado em 2013

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics

Por Bumbaca Yadav, Daniela, Sharma, Vikas K., Boswell, Charles Andrew, Hotzel, Isidro, Tesar, Devin, Shang, Yonglei, Ying, Yong, Fischer, Saloumeh K., Grogan, Jane L., Chiang, Eugene Y., Urban, Konnie, Ulufatu, Sheila, Khawli, Leslie A., Prabhu, Saileta, Joseph, Sean, Kelley, Robert F.
Publicado no J Biol Chem (2015)

Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye

Por Tesar, Devin, Luoma, Jacob, Wyatt, Emily A., Shi, Catherine, Shatz, Whitney, Hass, Philip E., Mathieu, Mary, Yi, Li, Corn, Jacob E., Maass, Katie F., Wang, Kathryn, Dion, Michelle Z., Andersen, Nisana, Loyet, Kelly M., van Lookeren Campagne, Menno, Rajagopal, Karthikan, Dickmann, Leslie, Scheer, Justin M., Kelley, Robert F.
Publicado no MAbs (2017)