Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation

For some antibodies intended for use as human therapeutics, reduced effector function is desired to avoid toxicities that might be associated with depletion of target cells. Since effector function(s), including antibody-dependent cell-mediated cytotoxicity (ADCC), require the Fc portion to be glyco...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:MAbs
Autors principals: Gong, Qian, Hazen, Meredith, Marshall, Brett, Crowell, Susan R., Ou, Qinglin, Wong, Athena W., Phung, Wilson, Vernes, Jean-Michel, Meng, Y. Gloria, Tejada, Max, Andersen, Dana, Kelley, Robert F.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
Matèries:
Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968109/
https://ncbi.nlm.nih.gov/pubmed/27216702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1189049
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars