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Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation
For some antibodies intended for use as human therapeutics, reduced effector function is desired to avoid toxicities that might be associated with depletion of target cells. Since effector function(s), including antibody-dependent cell-mediated cytotoxicity (ADCC), require the Fc portion to be glyco...
שמור ב:
| הוצא לאור ב: | MAbs |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Taylor & Francis
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4968109/ https://ncbi.nlm.nih.gov/pubmed/27216702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1189049 |
| תגים: |
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