Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation

For some antibodies intended for use as human therapeutics, reduced effector function is desired to avoid toxicities that might be associated with depletion of target cells. Since effector function(s), including antibody-dependent cell-mediated cytotoxicity (ADCC), require the Fc portion to be glyco...

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Publicado no:MAbs
Main Authors: Gong, Qian, Hazen, Meredith, Marshall, Brett, Crowell, Susan R., Ou, Qinglin, Wong, Athena W., Phung, Wilson, Vernes, Jean-Michel, Meng, Y. Gloria, Tejada, Max, Andersen, Dana, Kelley, Robert F.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968109/
https://ncbi.nlm.nih.gov/pubmed/27216702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1189049
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