Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity

Knobs-into-holes is a well-validated heterodimerization technology for the third constant domain of an antibody. This technology has been used to produce a monovalent IgG for clinical development (onartuzumab) and multiple bispecific antibodies.(1,2) The most advanced uses of this approach, however,...

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Detalhes bibliográficos
Main Authors: Shatz, Whitney, Chung, Shan, Li, Bing, Marshall, Brett, Tejada, Max, Phung, Wilson, Sandoval, Wendy, Kelley, Robert F, Scheer, Justin M
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896601/
https://ncbi.nlm.nih.gov/pubmed/23995614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26307
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