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In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation
Antibodies isolated from human donors are increasingly being developed for anti-infective therapeutics. These antibodies undergo affinity maturation in vivo, minimizing the need for engineering of therapeutic leads for affinity. However, the affinities required for some therapeutic applications may...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Landes Bioscience
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984332/ https://ncbi.nlm.nih.gov/pubmed/24492299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27875 |
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