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Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo
Apobec3/Rfv3 is an innate immune factor that promotes the neutralizing antibody response against Friend retrovirus (FV) in infected mice. Based on its evolutionary relationship to activation-induced deaminase (AID), Apobec3 might directly influence antibody class switching and affinity maturation in...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3024598/ https://ncbi.nlm.nih.gov/pubmed/20566830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001143 |
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