Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction

BACKGROUND: APOBEC3/Rfv3 restricts acute Friend retrovirus (FV) infection and promotes virus-specific neutralizing antibody (NAb) responses. Classical Rfv3 studies utilized FV stocks containing lactate-dehydrogenase elevating virus (LDV), a potent type I interferon inducer. Previously, we showed tha...

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Detalhes bibliográficos
Publicado no:Retrovirology
Main Authors: Barrett, Bradley S., Harper, Michael S., Jones, Sean T., Guo, Kejun, Heilman, Karl J., Kedl, Ross M., Hasenkrug, Kim J., Santiago, Mario L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392950/
https://ncbi.nlm.nih.gov/pubmed/28415995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-017-0349-2
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