Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection

Somatic hypermutation (SHM) is an integral process in the development of high-affinity antibodies that are important for recovery from viral infections and vaccine-induced protection. Ig SHM occurs predominantly in germinal centers (GC) via the enzymatic activity of activation-induced deaminase (AID...

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Detaylı Bibliyografya
Asıl Yazarlar: Halemano, Kalani, Guo, Kejun, Heilman, Karl J., Barrett, Bradley S., Smith, Diana S., Hasenkrug, Kim J., Santiago, Mario L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040588/
https://ncbi.nlm.nih.gov/pubmed/24821801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403361111
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