Immunoglobulin V(H) Gene Diversity and Somatic Hypermutation during SIV infection of Rhesus Macaques

B cell functional defects are associated with delayed neutralizing antibody development in pathogenic lentivirus infections. However, the timeframe for alterations in the antibody repertoire and somatic hypermutation (SHM) remains unclear. Here, we utilized the SIV/rhesus macaque (RM) model to inves...

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Detalhes bibliográficos
Publicado no:Immunogenetics
Main Authors: Guo, Kejun, Halemano, Kalani, Schmitt, Kimberly, Katuwal, Miki, Wang, Yaqiong, Harper, Michael S., Heilman, Karl J., Kuwata, Takeo, Stephens, Edward B., Santiago, Mario L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5439441/
https://ncbi.nlm.nih.gov/pubmed/25994147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00251-015-0844-3
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