Immunoglobulin V(H) Gene Diversity and Somatic Hypermutation during SIV infection of Rhesus Macaques

B cell functional defects are associated with delayed neutralizing antibody development in pathogenic lentivirus infections. However, the timeframe for alterations in the antibody repertoire and somatic hypermutation (SHM) remains unclear. Here, we utilized the SIV/rhesus macaque (RM) model to inves...

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Bibliografske podrobnosti
izdano v:Immunogenetics
Main Authors: Guo, Kejun, Halemano, Kalani, Schmitt, Kimberly, Katuwal, Miki, Wang, Yaqiong, Harper, Michael S., Heilman, Karl J., Kuwata, Takeo, Stephens, Edward B., Santiago, Mario L.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5439441/
https://ncbi.nlm.nih.gov/pubmed/25994147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00251-015-0844-3
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