Cellular HIV-1 Inhibition by Truncated Old World Primate APOBEC3A Proteins Lacking a Complete Deaminase Domain

The APOBEC3 (A3) deaminases are retrovirus restriction factors that were proposed as inhibitory components of HIV-1 gene therapy vectors. However, A3 mutational activity may induce undesired genomic damage and enable HIV-1 to evade drugs and immune responses. Here, we show that A3A protein from Colo...

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Publicat a:Virology
Autors principals: Katuwal, Miki, Wang, Yaqiong, Schmitt, Kimberly, Guo, Kejun, Halemano, Kalani, Santiago, Mario L., Stephens, Edward B.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252819/
https://ncbi.nlm.nih.gov/pubmed/25262471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.09.001
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