Cellular HIV-1 Inhibition by Truncated Old World Primate APOBEC3A Proteins Lacking a Complete Deaminase Domain

The APOBEC3 (A3) deaminases are retrovirus restriction factors that were proposed as inhibitory components of HIV-1 gene therapy vectors. However, A3 mutational activity may induce undesired genomic damage and enable HIV-1 to evade drugs and immune responses. Here, we show that A3A protein from Colo...

Full description

Saved in:
Bibliographic Details
Published in:Virology
Main Authors: Katuwal, Miki, Wang, Yaqiong, Schmitt, Kimberly, Guo, Kejun, Halemano, Kalani, Santiago, Mario L., Stephens, Edward B.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4252819/
https://ncbi.nlm.nih.gov/pubmed/25262471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.09.001
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items